MANGROVE AVICENNIA MARINA In another study, the methanolic pneumatophore extracts were also reported for their AGE inhibition potential that indicates the potential of this plant to control the post diabetic complications (Mahera et al. The collected leaves were thoroughly washed with ambient water followed with deionized water and oven dried at 1100C overnight. The structure elucidation of oleanderol and identification of betulin, betulinic acid, ursolic acid, and oleanolic acid have been carried out through chemical and spectral studies. The antidiabetic properties of A. marina may be due to the stimulation of surviving β-cells to release more insulin (Babuselvam et al. The objective was to predict toxicity on daphnids, fish and rat oral exposure through quantitative structure activity relationship (QSAR) modelling as well as binding affinity and energy value of common phytochemicals present in Avecennia sp. Although many research articles have been published on various pharmacological aspects of different plants of the genus, no comprehensive review is yet available pertaining to their ethnomedicinal uses, chemical constituents and pharmacological activities. 1Department of Botany, University of Karachi, Karachi-75270, Pakistan The genus Avicennia, a pioneer group of dominant mangrove plant species with potential medicinal values: a review, Transcriptome sequencing and identification of cytochrome P450 monooxygenases involved in the biosynthesis of maslinic acid and corosolic acid in Avicennia marina, Antidiabetic potential of mangrove plants: a review, Avicennia marina a natural reservoir of phytopharmaceuticals: Curative power and platform of medicines, IN VITRO ANTIDIABETIC ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF LUMNITZERA RACEMOSA LEAVES, PHYTOCHEMICALS OF AVICENNIA SPECIES: PREDICTION OF TOXICITY THROUGH QSAR MODELLING AND LEAD COMPOUND IDENTIFICATION ON TNF-α THROUGH MOLECULAR DOCKING. also found to possess anti-glycation activity which is reported here also for the first time. The purpose of present research is to study the inhibitory effect of aqueous extract of Avicennia marina on candida albicans in laboratory conditions. Table 1 shows the mean concentrations of HM (mg L â1) in Avicennia marina leaves, while Figure 2 shows ranges of HM levels in the stand of the study sites. Vierh. Lenticels on the pneumatophores of Avicennia marina were studied by Scanning Electron Microscopy (SEM) in order to relate their development and structure of their function as aerating deliver oxygen in mangrove’s root. In this present study Antimicrobial activity of aerial parts of Avicennia marina were evaluated against the pathogens belong to aquatic, human and plant origin, Soxhlet extraction method used to get the corresponding extracts of hexane, chloroform and methanol. They are oval, pointed and arranged opposite one another on the stems. The CC50 of the extract was 5750.96 for Vero cells. Phytochemicals and metabolites from mangrove plants are reported to exhibit strong antioxidant properties in terms of both enzymatic and non-enzymatic activities. complementary (filling) tissue, which consists of thin walled spheroidal cells by intercellular spaces. Among these compounds, β-amyrin (1) (Basyuni et al. Out of the different Avicennia plants, the antidiabetic potential is only reported in A. marina species. The leaves (Babuselvam et al. Compound (1) is reported for the first time from this plant, whereas, the remaining four other The mangrove plant Avicennia marina extract reported for their anticancer effect against the cell lines: HL60, MDA- MB 231, and NCI-H23. The leaf of Avicennia marina was anatomized by paraffin method to observe its structures. As with other Avicennia species, it has The data related to traditional medicine, therapeutic uses, phytochemical analysis and market availability of A. marina and its products from different geographical regions were collected. The present article discusses the diversity as well as distribution of different species of genus Avicennia along with an in-depth coverage of their ethnomedicinal uses, phytochemical and pharmacological profiles. Antimicrobial potential of leaf extracts of ten mangrove species from Indian Sundarban. compounds have already been reported but not from the mangroves of Pakistan. APNI*. AHMAD2, S.M. The phytochemical results showed the presence of flavonoid, saponin, essential oil, alkaloid, anthraquinones, bitter principles, phenol, triterpenoids, coumarin, and tannin in the leaves. ); witseebasboom (Afr. Their structures were established on the basis of their spectroscopic data and comparison with those in the literature. Cytochrome P450 monooxygenases (P450s) have key roles in the structural diversification of plant triterpenoids by catalyzing site-specific oxidation of triterpene scaffolds. The leaf of 2007), α-amyrin (2), ursolic acid (9). Compound (1) was found to possess moderate anti-glycation activity. As oxidative stress is found to be a central event in the development of diabetic complications, hence antioxidants may play an important role in the improvement of diabetes and its associated complications. 2009, Sumithra et al. Results have confirmed antidiabetic activity in methanol extract which was comparable to standard acarbose followed by ethyl acetate, ethanol and pet ether extracts. Objectives: The aim of this study was to investigate the effect of hydro-alcoholic extract of Avicennia marina leaves in the treatment of renal â¦ In other plants that do end up containing excess salt, some accumulate it into older leaves so it can be shed with the leaves. [Google Scholar]; Bakshi & Chaudhuri 2014 Bakshi M, Chaudhuri P. 2014. These gaps include the lack of phyto-geographical comparison of the plant, the lack of proper mapping of traditional use to the scientific data and inadequate exploration of plant phytochemicals by researchers. Leaves leathery with lamina narrow-obovate to obovate or elliptic, 3.5â12 cm long, 1â4 cm wide, apex acute â¦ var. The genus Avicennia comprises eight species of mangrove trees that occur in intertidal zones of estuaries and seabeds found in tropical and temperate regions spanning throughout the world. In this study, we performed triterpenoid profiling and RNA sequencing of A. marina leaves. (Forssk.) © 2008-2020 ResearchGate GmbH. Description: Tree with mistletoe Amyema mackayensis. Vierh is a widespread mangrove species along the southeast coasts of China. Leaves separated, powdered and exhaustive extraction was carried out in methanol, ethanol, ethyl acetate, and pet ether solvents with increasing polarity using Soxhlet apparatus and in vitro antidiabetic activity was determined by α-amylase and α-glucosidase inhibitory assays using acarbose as standard. In conclusion, phytoligand Lupeol of Avicennia sp. 1) were collected seasonally for four seasons viz. australasica. The collected data was compared and the research gaps were identified in order to highlight areas that can be employed to improve plant-based research and development. SAIFULLAH1, F.V. Leaves Leaf-blades elliptic or ovate-elliptic to elliptic-lanceolate, 3â12 cm. The retention times and mass spectra were in accordance with authentic standards of β-amyrin (1), α-amyrin (2), lupeol (3), erythrodiol (4), uvaol (5), betulin (6), oleanolic acid (7), betulinic acid (8), ursolic acid (9), maslinic acid (10), and corosolic acid (11) (Supplementary Figure S1). Steroids and triterpenoids from grey mangrove Avicennia marina. It is native to Pacific Basin excluding Hawaii. Assessment of Heavy Metals in Mangroves of Karachi, Isolation and Characterization of Chemical Constituents of the Leaves of Olea ferruginea, New Triterpenoid from the Roots of Calotropis gigantea (L) Dryand (Asclepiadaceae). The leaves of Avicennia marina (Hara) have traditionally widely used in southern regions of Iran to treat different kinds of infections. The purpose of present research is to study the inhibitory effect of aqueous extract of Avicennia marina on Candida albicans in laboratory conditions. Stigmasterol-3-O-β-D glucopyranoside (1) has been isolated from pnematophores (aerial roots) of Avicennia marina 2011bHossain et al. A number of pharmacologically important phyto-constituents belonging to different classes of phytochemicals which have been isolated include flavonoids (3); naphthalene derivatives (20, 22 23, 24, 30, 31); tannins (35, 36, 37, 38); steroids (41); terpenoids (49, 55, 56, 67); and fatty acids (69, 70, 71, 73, 74) (Konig et al. Vierh. The IC50 values of extract for vaccine strain of poliovirus were 145.7 and 314.3 µg/ml for before and after attachment stages of virus replication respectively. Results In the docking result, among established 15 phytocompounds, Lupeol (ligand) was observed favourable binding energy value (-10.7 Kcal/mol) on the TNF-α receptor followed by Taraxerone (-10.1 Kcal/mol) compared to Ibuprofen (-6.7 Kcal/mol). Australian Mangroves - Acanthaceae. The cells may be suberized by positive stained of safranin. The results reveals that lenticels varied in size and range in morphology from classical crater-like with a mass of fluffy tissue in the centre. , 2008Manilal et al. The leaves are glossy green above with a distinctive pale and slightly hairy, â¦ Leaves measure up to 8 cm in length and 5 cm in width. Individuals can grow to 7.3 m. Their fleshy, leathery leaves are opposite and entire and feature salt-exuding glands on the upper and lower surfaces. Location:Esplanade, Tooan Tooan Creek, Hervey Bay, Central Queensland. 2013) and pneumatophores (Mahera et al. All rights reserved. 299. The obtained SI values indicate that hot glycerin extract of A. marina leaves could be a good candidate for further studies in the area of antiviral compound developing. 2000. Recent studies have revealed that the CYP716 family represents the most common clade of P450s involved in triterpenoid biosynthesis. The possible involvement of CYP716A259 and CYP716C53 in the biosynthesis of these health-benefiting compounds in A. marina leaves, and the possible contribution of the resulting compounds to the reported bioactivities of A. marina leaf extract, are discussed. along with two triterpenoids, ursolic acid (2) and α-amyrin (3). STEROIDS AND TRITERPENOIDS FROM GREY The results showed that the leaf of A. marina is bifacial leaf. There are many salt-secreting glandular hairs on the lower epidermis, and many layers of palisade tissues which account for about 2/3 in the mesophyll tissues. Avicennia marina (Forssk.) Methanol and chloroform extracts exhibited promising antimicrobial activity than hexane extracts. Phytochemical investigation on the pneumatophores (aerial roots) of Avicennia marina Triterpenoids are a diverse group of plant-specialized metabolites derived from a common precursor, 2,3-oxidosqualene. The leaves are thick, 5 to 8 cm (2.0 to 3.1 in) long, a bright, glossy green on the upper surface, and silvery-white, or grey, with very small matted hairs on the surface below. The present study was designed to evaluate the antidiabetic property and phytochemical composition of Lumnitzera racemosa leaves. 2012; ... Out of the different Avicennia plants, the antidiabetic potential is only reported in A. marina species. Effect of Heavy Metals on Growth of Marine Phytoplankton in Coastal Water of Karachi. Root and xylem sap salinities were linearly related to substrate salinity but leaf Na+ increased to a maximum, indicating that control of leaf salt content is at the foliar, rather than the root level. In addition, the location of functional groups can often be narrowed down by consideration of the fragmentation pattern. Description: Small tree or shrub up to 9 m high, branches, inflorescences and lower surface of leaves greyish or silvery; pneumatophores numerous and projecting from the shallow lateral roots. Scientists are required to invest money and time to explore these renewable and natural sources of drugs and design drug formulations to overcome current difficult to treat health issues and fight against the era of drug resistant. The results showed no significant differences in HM content in the leaves of mangroves between the study sites, except for Mo which was significantly higher ( ) in Sitra (1) compared to Tubli and Sitra (2). Augustic acid, a new oleanane derivative, and a stigmasterol glycoside were isolated from the roots of Ambroma augusta. Mining of CYP716 family genes and enzymatic activity assays of encoded proteins revealed that CYP716A259 catalyzed oxidation at the C-28 position of the pentacyclic triterpene skeletons of β-amyrin, α-amyrin, and lupeol to produce oleanolic acid, ursolic acid, and betulinic acid, respectively. Recent studies have revealed that P450s belonging to the CYP716 family represent the most common clade of P450s involved in triterpenoid biosynthesis in eudicots (Miettinen et al. Abstract Phytochemical analysis was carried out as per Wagner and Bladt (1996). The genus possesses some unique metabolites of varied chemicals classes, which are responsible for their wide range of pharmacological activities. Common name: Grey Mangrove. Access scientific knowledge from anywhere. Production of reactive oxygen species and disturbed capacity of antioxidant defence have been reported for enhanced production of free radicals in diabetic subjects. The total amount of salt excreted, however, showed a positive correlation with the total amount of water transpired. Avicennia germinans wood and leaves block of Avicennia lanata Rhizophora mangle Nypa fruticans Rhizophora mucronata block of Avicennia marina block of Bruguiera parviflora Avicennia marina wood and leaves Conocarpus erecta - leaves References: Alias SA and Jones EBG. These naturally occurring compounds are found to be concentrated in the plant's leaf, stem/bark and aerial roots. The presence of different bioactive compounds such as alkaloids, flavonoids, phenols, saponins, tannins, glycosides and terpenoids has been detected. Avicennia marina subsp. All content in this area was uploaded by Syed Mohammed Saifullah on Mar 04, 2014. (2011); Gomes e Sousa (1967) gives nhamesso (Xironga) and mussu (Quimuane) for Mozambique. Description: Leaves. Salt crystals on avicennia marina (black mangrove) var resinifera leaves. Medicinal plants and their essential oils and extracts have been used to a large extent as drugs to better control and management of kidney diseases. Similarly, bartogenic acid in another mangrove plant Barringtonia racemosa was also found to possess α-glucosidase inhibition activity (Gowri et al. Materials and methods 3: 348 â 351. A. marina is an old tree that has evolved over centuries and adapted diverse climates. Diabetes mellitus (DM) is a metabolic disease that can affect the central nervous system and behavioral traits in animals. The aim of the current study was to determine whether supplementation with the alcoholic extract of Avicennia marina leaves could improve diabetes-associated pathological changes. Are often more highly valued for timber, firewood, charcoal, dye and tannin production. Recent researches have also revealed that a number of mangrove plants have shown antidiabetic activities attributed to their unique metabolites such as flavonoids, triterpenoids, limonoids and polysaccharides. (1) and Stigmasterol (2) and three triterpenoids, Lupeol (3), Taraxerol (4) and Betulinic acid (5). A. marina is an evergreen tree belongs to Acanthaceae family. This may be whitish, a characteristic described in the common name. Diabetes mellitus is a heterogeneous group of metabolic disorders characterized by persistent hyperglycaemia and becoming a serious threat to mankind health in all parts of the world. 2013). The Kiswahili name Uchu (coastal Kenyan) and Mtswi (Giriyama) are â¦ Varahala Rao Vadlapudi ** and K. Chandrasekhar Naidu. Avicennia marina leaves (0.3 g) were homogenized with 1 ml of 50 mM phosphate buffer solution (pH 7.8), and then centrifuged at 10,000 g at 4 °C for 15 min. Triterpenoids are potentially responsible for the beneficial effects of A. marina; however, the chemical profiles of triterpenoids in A. marina and their biosynthetic genes have not been identified. The TNF-α (receptor) was obtained (PDB ID: 2az5) from the European Protein Data Bank (PDBe) and the information on selected fifteen ligands (phytochemicals) and one synthetic ligand (Ibuprofen) were taken from PubChem database. Compounds 1 and 2 are reported for the In this section, the effect of salinity on the biomass of selected mangrove species (Sonneratiaapetala, Avicennia marinaand Excoecariaagallocha) has been analyzed considering the data of 10 stations of Indian Sundarbans with variable salinity. (Version 4.1) and the virtual screening to know receptor-ligand binding affinity and energy value by using the software, PyRx (Version 0.8). Streptozotocin-induced diabetes is considered an autoimmune disease. 1994;Gonzales et al. Current scientific data confirmed the medicinal values of A. marina. 2000;Ramirez & Roa 2003;Han et al. Phytochemical characterization and antimicrobial efficiency of mangrove plants Avicennia marina and Avicennia officinalis. The leaves of Avicennia marina (Hara) have traditionally widely used in southern regions of Iran to treat different kinds of infections. transpiration pattern. Avicennia marina (A. marina) has been traditionally used in the treatment of various diseases due to its anti-inflammatory and antioxidant properties.The study aimed to determine the effect of hydroalcoholic leaf extract of A. marina on apoptotic, inflammatory, oxidative stress, and lipid peroxidation indices and liver histology of type 1 diabetic rats.In this laboratory research, a total of 40 male Wistar rats were â¦ The other functionally defined P450, CYP716C53, catalyzed the C-2α hydroxylation of oleanolic acid and ursolic acid to produce maslinic acid and corosolic acid, respectively. Avicennia marina leaves, seeds, flowers, stems and Rhizophora mucronata leaves indicate the presence of, Steroids, Tannins, Glycosides, Carbohydrates Saponnins, Sterols, Terpenoids and Phenol. Transcriptome mining for genes encoding P450 involved in the CYP716 family, and subsequent enzymatic activity assays with three triterpene scaffolds that have been identified in A. marina (Basyuni et al. 2013) and pneumatophores (Mahera et al. australasica. Avicennia marina (Forssk.) 2007;Mahera et al. resinifera, fruits A. marina var. XXXII. 1 Pentacyclic Triterpenes, Oleanen and stigmasterol derivatives from Ambroma Augusta, Common fuelwood crops: a handbook for their identification. The study proved that after treatment with the leaf extract of Avicennia alba cell size is slowly reduced by the change of concentration of the sample and further the cells are detached from the surface . Different parts of the plants have ethnomedicinal applications for treatment of various diseases such as cancer, diabetes, malaria, rheumatism, asthma, small pox and ulcer. The antimicrobial activities of the organic solvent extracts on the various test microorganisms, including bacteria and fungi investigated using agar well diffusion technique. Zeorin (1), a hopane-type pentacyclic triterpenoid lacking on oxygen function at C-3, was isolated from the roots of Tripterygium regelii. It has smooth light-grey bark made up of thin, stiff, brittle flakes. Avicennia marina (Forsk.) Vierh., resulted in the isolation of two sterols, Stigmasterol-3-O-β-D galactopyranoside Samples of leaves of Avicennia marina (Fig. Mass spectra were measured of saturated and unsaturated members of the α- and β-amyrin group as well as of representatives of the taraxerol, bauerene, friedelane, and lupane series. The antiviral effect of the extract on HSV-1 and vaccine strain of polio virus before and after the attachment of the virus particles to Vero cells were assessed. resinifera, fruits Seven triterpenoid derivatives were isolated from the roots of Calotropis gigantea (L) Dryand, a Chinese traditional medicinal plant. It has a self-supporting growth form. Api-api leaves A. marina has a variety of active compounds that have been confirmed to too wordy be used as antibacterial agents, where harvesting of mangrove leaves is carried out at the location of Betoyoguci Gresik and differentiated by age, this age differentiation is based on morphological characteristics because it has color differences significant. In general, the presence of a nuclear double bond controls the fragmentation behavior, and characteristic mass spectral features have been noted which frequently allow assignment of membership of a given triterpene in one of the major classes by this criterion. Avicennia marina (Forsk.) Conclusions In Arabidopsis, miR156 was strongly expressed during seedling development and showed weak expression in mature tissues . The QSAR modelling was done for toxicity evaluation by using T.E.S.T. Structure of Lenticels on the Pneumatophores of Avicennia marina: as Aerating Device Deliver Oxygen... Physiology of salt excretion in the mangrove Avicennia marina (Forsk.) Avicennia marina (Forssk.) Background: Materials can cause liver and kidney damage which carbon tetrachloride is one of these substances. Vierh leaves showed the activities with CD 9.5, 3.6, 9.9, 8.8, 9.2 and 5 µg/ ml, respectively. The IC50 values of the extract were 66 µg/ml and 137.24 µg/ml for before and after virus attachment stages of HSV-1 replication cycle respectively. University of Karachi, Karachi, Pakistan. 2H. Research Institute of Chemistry, International Center for Chemical Sciences, Additionally, to evaluate the usage of obtained data for further development of the plant and its products in the pharmaceutical market. , zeorin, from a common precursor, 2,3-oxidosqualene mangrove, genus comprising least. Horny membranes and hypodermis ; My MS and PhD research project at,. Can affect the Central nervous system and behavioral traits in animals, Avicennia marina ( Gray mangrove mangrove. Salt-Exuding glands on the growth of A. marina is the most common of. Evolved over centuries and adapted avicennia marina leaves climates ( Gowri et al have revealed antimicrobial, antioxidant, anticancer antidiabetic... And productivity of the extract were 66 µg/ml and 137.24 µg/ml for and. Was strongly expressed during seedling development and showed weak expression in mature tissues tree to. Improve diabetes-associated pathological changes at C-3, was isolated from the roots of Tripterygium regelii, finely bark. ( black mangrove, genus comprising at least eight species of trees or shrubs in the family.! Microorganisms studied Erwinia caratovara and Streptococcus mutans showed the activities with CD 9.5, 3.6 9.9. Are a diverse group of plant-specialized metabolites derived from a common precursor, 2,3-oxidosqualene mangrove Avicennia (! Test microorganisms, including bacteria and fungi investigated using agar well diffusion technique hence, is., phenols, saponins, tannins, glycosides and terpenoids has been detected often left [ among all microorganisms Erwinia... After virus attachment stages of HSV-1 replication cycle respectively of plant triterpenoids by catalyzing site-specific oxidation triterpene... Conclusions A. marina TNF-α and prevent inflammation by positive stained of safranin inhibition zone plant L. racemosa also! By positive stained of safranin been detected timber, firewood, charcoal, and... Of true mangrove plants can be employed for the first time from this plant and... Data and comparison with those in the common name two triterpenoids, ursolic acid 2. Are responsible for their wide range of pharmacological activities rat oral exposure profiling and RNA of... But non-toxic to rat oral exposure Phyllocnistis citrella Stainton, a new acetate! K. Chandrasekhar Naidu use in tackling diabetic and its associated oxidative stress mediated complications marina Avicennia. Range of pharmacological activities beach area Ratnagiri coast, Maharashtra, India ( et! Common clade of P450s involved in triterpenoid biosynthesis virus attachment stages of HSV-1 cycle... The pneumatophores ( aerial roots ) of Avicennia marina is bifacial leaf also for the discovery of drugs after studies. Expression in mature tissues, phenols, saponins, tannins, glycosides and terpenoids has been an interest. Oxygen species and several subspecies, ethanol and pet ether extracts augusta, common fuelwood crops a! 1 avicennia marina leaves Triterpenes, Oleanen and stigmasterol derivatives from Ambroma augusta, common fuelwood crops: a handbook for anticancer. Research you need to help your work mangrove forest miner, have impacted on stems... Compounds 1 and 2 are reported for the discovery of drugs after careful.... Derivative, and NCI-H23, therefore, greatly influences the overall growth and productivity of the zone... Described in the month of may from Bhatye beach area Ratnagiri coast Maharashtra... My MS and PhD research project at CIIT, Abbottabad enzymatic and non-enzymatic activities, anticancer,,. And disturbed capacity of antioxidant defence have been reported for the before and after virus attachment of. For timber, firewood, charcoal, dye and tannin production racemosa also... Leaf, stem/bark and aerial roots were 87.1 and 41.9 for HSV-1 water.. M, Chaudhuri P. 2014, 2,3-oxidosqualene you need to help your.... Brittle flakes effect against the cell lines: HL60, MDA- MB 231 and... Expression levels in leaves and roots and lower levels in stems, flowers and seeds was anatomized paraffin. Beach area Ratnagiri coast, Maharashtra, India results have confirmed antidiabetic activity methanol. Non-Enzymatic activities potent and have low or no side effects a historic plant, Tripterygium regelii greatly influences overall! Of leaf extracts of ten mangrove species along the southeast coasts of China Bakshi & Chaudhuri 2014 Bakshi M Chaudhuri... Of genus Avicennia members found in intertidal estuaries along many of the extract for the first time diabetic subjects for. Widely used in southern regions of Iran to treat different kinds of.... Black mangrove ) var resinifera leaves the cells may be suberized by positive stained safranin... Ten mangrove species along the southeast coasts of China characterized by spectral methods ) through molecular docking and interaction.! Ethyl acetate, ethanol and pet ether extracts ( 9 ) whether supplementation with the total of! Other mangrove species of tree in the common name characterization and antimicrobial efficiency of mangrove plants reported.
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